Why the study?
Does hypothermia increase the susceptibility of the dog heart to calcium-induced ventricular fibrillation?
Does hypothermia increase the susceptibility of the dog heart to calcium-induced ventricular fibrillation?
Hypothermia significantly increases the sensitivity of the canine myocardium to calcium-induced ventricular fibrillation.
Hypothermia may heighten Ca-induced VF risk in canine models; leaves open translation to clinical hypothermia.
The susceptibility of the dog heart to ventricular fibrillation (VF) induced by CaCl 2 infusions is several fold greater in hypothermia than in normothermia, i.e., both the amount of CaCl 2 infused and the terminal plasma levels are found to be less in hypothermia. Dogs rendered hypercalcemic prior to hypothermia induction also succumb to ventricular fibrillation, and at relatively high heart temperatures (22-27 C.), whereas those rendered hypocalcemic by Na-EDTA infusions succumb to asystole at much lower temperatures (14-18 C.). The calcium sensitivity is not pH dependent either at normal or low temperatures.
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Angelakos et al. (1957) studied this question.