Population
Clonal rat insulinoma tumor and hamster insulinoma tumor beta cell lines, and normal rat pancreatic islet…
Comparison
Electrophysiological characterization using… vs Comparison between RINm5f cells and HIT cells
Design
Preclinical
Authors
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Cell line-specific BK inactivation warrants caution extrapolating to native beta cells; leaves open their role in insulin secretion.
The study demonstrates that RINm5f cells express rapidly inactivating BK channels while HIT cells express noninactivating BK channels, which may explain differences in their electrical responses to secretagogues.
Li et al. (1999) studied this question.
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