Population
Rat islets and MIN6 mouse insulinoma cells
Comparison
Stimulation of cAMP production with… vs Normal conditions or basal glucose concentrations
Design
Preclinical
Authors
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HCN inhibition unlikely to modulate insulin secretion; leaves open any beta-cell role or species differences in animal models.
This study provides the first evidence for functional expression of HCN channels in pancreatic beta-cells, although their inhibition did not alter glucose-stimulated insulin secretion.
El-kholy et al. (2006) studied this question.
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