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September 1, 2015EP EuropaceOpen Access

A U-shaped association was observed: ≥2000 hours of lifetime endurance sport activity increased AF risk (OR 3.88 [1.55-9.73]), while <2000 hours protected against AF (OR 0.38 [0.12-0.98]) compared to sedentary individuals.

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Why the study?

Does the dose of high-intensity endurance training affect the risk of lone atrial fibrillation?

Population

172 individuals (115 patients with lone atrial fibrillation and 57 age- and sex-matched healthy controls)

Comparison

High-intensity endurance training, along with… vs Sedentary individuals / healthy controls

Design

Case-control

Authors

NCNaiara CalvoPRPablo RamosSMSílvia Montserrat

Discussion

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Overview

High-intensity exercise shows U-shaped lone AF association; hypothesis-generating for activity thresholds and emerging risks in observational data.

Structured PICO

Does the dose of high-intensity endurance training affect the risk of lone atrial fibrillation?

P
Population
172 individuals (115 patients with lone atrial fibrillation and 57 age- and sex-matched healthy controls)
I
Intervention
High-intensity endurance training (evaluated by accumulated lifetime hours), along with other emerging risk factors (height, waist circumference, obstructive sleep apnoea)
C
Comparator
Sedentary individuals / healthy controls
O
Outcome
Risk of lone atrial fibrillation (Ln-AF)

There is a U-shaped dose-response relationship between high-intensity endurance training and lone atrial fibrillation, where moderate amounts (<2000 hours) are protective but high amounts (≥2000 hours) increase risk.

Cite This Study

Calvo et al. (2015) studied this question.

synapsesocial.com/papers/6a70a344a528af2d65c3a77dhttps://doi.org/10.1093/europace/euv216
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relationship between reported endurance exercise and atrial fibrillation in middle-aged males2025
  2. 2Association of Self-reported Sports Volume and Discipline with Atrial Arrhythmia Prevalence in Middle-Aged Males2026 · 1 citations
  3. 3Is exercise becoming a danger for our health? The complex relationship between exercise and atrial fibrillation2018 · 5 citations
  4. 4Risk of incident atrial fibrillation detected on implantable loop recorder and relationship with physical activity; an individual participant pooled analysis of LOOP and VENTOUX2026
  5. 5The timing and relationship of atrial fibrillation with exercise in veteran male endurance athletes2026