Why the study?
Established organ-scale computational models cannot capture the impact of local conduction heterogeneities on global arrhythmic excitation patterns.
A novel computational approach for modeling cardiac electrical excitation better captures the impact of local conduction heterogeneities and re-entry compared to established methods.
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Computational models may clarify tissue remodelling effects on arrhythmias; leaves open clinical translation pending validation.
Colman et al. (2022) studied this question.
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