Why the study?
Does immobilized human thrombomodulin on glass beads exhibit anticoagulant activity and inhibit platelet aggregation in human blood?
Does immobilized human thrombomodulin on glass beads exhibit anticoagulant activity and inhibit platelet aggregation in human blood?
Immobilization of human thrombomodulin on glass beads successfully demonstrates anticoagulant and antiplatelet activity in vitro.
Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood.
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Akashi et al. (1992) studied this question.
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