Synovial Sarcoma: A Multivariate Analysis of Prognostic Factors in 112 Patients With Primary Localized Tumors of the Extremity
Why the study?
What are the independent prognostic factors for recurrence and mortality in patients with primary synovial sarcoma of the extremity?
Population
112 patients with primary synovial sarcoma localized to the extremity who underwent surgical resection for…
Design
Cohort
Follow-up
median 72 months among survivors
Authors
Discussion
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Member takes
Implication
May support risk stratification by size and invasion; leaves open impact on adjuvant decisions pending prospective validation.
Structured PICO
What are the independent prognostic factors for recurrence and mortality in patients with primary synovial sarcoma of the extremity?
P
Population
112 patients with primary synovial sarcoma localized to the extremity who underwent surgical resection for cure
I
Intervention
Surgical resection and evaluation of clinical and pathologic prognostic factors
O
Outcome
Time to first local recurrence not preceded by distant recurrence, time to any distant recurrence, and time to disease-related mortalityhard clinical
In patients with primary synovial sarcoma of the extremity, tumor size ≥ 5 cm and invasion of bone or neurovascular structures are independent predictors of distant recurrence and mortality.
Cite This Study
Lewis et al. (2000) studied this question.