Population
Isolated rat cardiac myocytes
Comparison
Supernatants of stimulated neutrophils, hydrogen… vs Hypoxia-reoxygenation (H/R) alone
Design
Preclinical
Follow-up
20 min of reoxygenation
Authors
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May exacerbate myocyte injury via neutrophil mediators; hypothesis-generating for targeted interventions in ischemia-reperfusion.
Neutrophil-released mediators, specifically hydrogen peroxide and elastase, exacerbate injury in isolated rat cardiac myocytes subjected to hypoxia-reoxygenation.
Buerke et al. (1994) studied this question.
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