Population
Isolated cardiomyocytes from Wistar rats with congestive heart failure induced by left coronary artery…
Comparison
Exposure to 4 hours of hypoxia and 2 hours of… vs Cardiomyocytes from sham-operated rats exposed…
Design
Preclinical
Authors
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Paradoxical ischemic tolerance in failing cardiomyocytes; hypothesis-generating and requires validation in human models before any clinical consideration.
Cardiomyocytes from failing rat hearts paradoxically demonstrate improved tolerance to ischemia-reperfusion injury, likely due to reduced sodium and calcium accumulation.
Sharikabad et al. (2009) studied this question.
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