Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 11, 2017BMC Infectious DiseasesOpen Access

Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do specific viral pathogens or multiple viral infections correlate with disease severity and management in pediatric acute respiratory tract infections?

Population

560 acute respiratory tract infection episodes in 520 children <12 years old presenting to the emergency…

Comparison

Detection of single or multiple viral… vs Negative RT-PCR results, or comparison between…

Design

Cohort

Authors

JWJérôme O. WishauptTPTjeerd van der PloegRGRonald de Groot

Discussion

Loading...

Member takes

Overview

RT-PCR positivity signals greater severity but not virus-specific patterns or worse outcomes with co-infections; leaves open routine broad testing in pediatric ARI.

Structured PICO

Do specific viral pathogens or multiple viral infections correlate with disease severity and management in pediatric acute respiratory tract infections?

P
Population
560 acute respiratory tract infection (ARI) episodes in 520 children <12 years old (mean age 7.9 months, 60.5% male) presenting to the emergency department or pediatric outpatient clinic in the Netherlands. Excluded: underlying anatomical airway abnormalities, significant underlying disorders (e.g., syndromal disorders, psychomotor retardation, malignancies), and newborns hospitalized since birth.
I
Intervention
Detection of single or multiple viral respiratory infections via RT-PCR (testing for 15 viruses and 2 bacteria).
C
Comparator
Negative RT-PCR results, or comparison between different specific viral pathogens.
O
Outcome
Correlation between clinical data (disease severity score, length of hospital stay, management) and specific viral pathogens.

In pediatric acute respiratory tract infections, disease severity and clinical outcomes are not associated with specific viral pathogens or the presence of viral co-infections.

Limitations

  • Subjective distinction of mild, moderate, and severe cough and rhinorrhea could not be made in the dataset for the disease severity score
  • Hoarseness was not included in the modified disease severity score
  • Further research with an extended panel of RT-PCR assays and a larger number of inclusions is necessary to further validate findings

Cite This Study

Wishaupt et al. (2017) studied this question.

synapsesocial.com/papers/6a70a9398031ec7bb1dc7e71https://doi.org/10.1186/s12879-016-2118-6
View Full Paper
Ask AI
Bookmark
Share