Key result
Multiple viral infections are not linked to worse bronchiolitis severity versus mono-infections in children.
Why the study?
The clinical relevance of detecting multiple viruses by RT-PCR in children with bronchiolitis and its association with disease severity remains unclear.
Does infection with multiple viruses increase disease severity in children with bronchiolitis?
Observational (n=142)
Does infection with multiple viruses increase disease severity in children with bronchiolitis?
Infection with multiple respiratory viruses does not increase disease severity in children with bronchiolitis compared to mono-infection.
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Multiple viral co-infections do not warrant escalated bronchiolitis care; leaves open virus-specific effects in larger prospective cohorts.
Brand et al. (2011) conducted an observational in bronchiolitis (n=142). Infection with multiple viruses vs. Mono-infection was evaluated on Disease severity (mild, moderate, severe). Infection with multiple viruses (detected in 41% of 142 samples) was not associated with increased disease severity in children with bronchiolitis compared to mono-infections.
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