Direct numerical simulations demonstrate that diastolic flow patterns in the left ventricle significantly influence blood mixing and cell residence time, despite having a negligible effect on overall pumping power.
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Diastolic flow effects on mixing may relate to thrombosis risk; leaves open any role in guiding clinical management.
Direct numerical simulations are used to study the effect of intraventricular flow patterns on the pumping efficiency and the blood mixing and transport characteristics of the left ventricle. The simulations employ a geometric model of the left ventricle which is derived from contrast computed tomography. A variety of diastolic flow conditions are generated for a fixed ejection fraction in order to delineate the effect of flow patterns on ventricular performance. The simulations indicate that the effect of intraventricular blood flow pattern on the pumping power is physiologically insignificant. However, diastolic flow patterns have a noticeable effect on the blood mixing as well as the residence time of blood cells in the ventricle. The implications of these findings on ventricular function are discussed.
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Seo et al. (2013) studied this question.
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