Association of Obesity and Survival in Systolic Heart Failure After Acute Myocardial Infarction: Potential Confounding by Age
Why the study?
Does obesity improve survival in post-acute myocardial infarction patients with systolic heart failure?
Population
6,561 post-acute myocardial infarction patients with systolic heart failure and BMI ≥ 18.5 kg/m² from the…
Comparison
Obesity (BMI ≥ 30 kg/m²) vs Non-obese (BMI 18.5-29.9 kg/m²)
Design
Cohort
Follow-up
median 16 months
Authors
Discussion
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Member takes
Implication
Matching abolishes apparent obesity survival benefit in post-AMI systolic HF; confirms confounding by age and leaves causal effect open.
Structured PICO
Does obesity improve survival in post-acute myocardial infarction patients with systolic heart failure?
P
Population
6,561 post-acute myocardial infarction (AMI) patients with systolic heart failure (HF) and BMI ≥ 18.5 kg/m² from the EPHESUS trial.
I
Intervention
Obesity (BMI ≥ 30 kg/m²)
C
Comparator
Non-obese (BMI 18.5-29.9 kg/m²)
O
Outcome
All-cause mortalityhard clinical
The apparent survival benefit of obesity (the 'obesity paradox') in post-AMI systolic heart failure is largely explained by confounding from the younger age of obese patients.
Cite This Study
Wu et al. (2010) studied this question.