Effect of partial agonist activity in beta blockers in severe angina pectoris: a double blind comparison of pindolol and atenolol.
Why the study?
Does pindolol compared to atenolol improve angina symptoms and ischemic parameters in patients with severe angina pectoris?
Population
15 patients with severe coronary artery disease, initially not taking any antianginal drugs
Comparison
Pindolol 5 mg oral thrice daily for five days vs Atenolol 100 mg oral daily for five days
Design
RCT, randomised manner, double blind
Follow-up
5 days per treatment period
Authors
Discussion
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Member takes
Implication
Supports preferring atenolol over pindolol for severe angina; confirms advantage of beta-blockers lacking partial agonist activity.
Structured PICO
Does pindolol compared to atenolol improve angina symptoms and ischemic parameters in patients with severe angina pectoris?
P
Population
15 patients (8 with effort angina and 7 with effort and nocturnal angina) with severe coronary artery disease, initially not taking any antianginal drugs
I
Intervention
Pindolol 5 mg oral thrice daily (with partial agonist activity) for five days
C
Comparator
Atenolol 100 mg oral daily (without partial agonist activity) for five days
O
Outcome
Daytime and nocturnal resting heart rates and the frequency of anginasurrogate
In patients with severe angina, beta-blockers without partial agonist activity (atenolol) are superior to those with partial agonist activity (pindolol) in reducing heart rate, angina frequency, and ischemia.
Cite This Study
Quyyumi et al. (1984) studied this question.