Key result
Pindolol resulted in less bradycardia, cold hands and feet, and tiredness compared to atenolol at 6 months in patients with hypertension.
Why the study?
Does pindolol reduce side-effects compared to atenolol in patients with essential hypertension?
RCT (n=349)
Double-blind
Yes
Does pindolol reduce side-effects compared to atenolol in patients with essential hypertension?
In the treatment of essential hypertension, pindolol (a beta-blocker with intrinsic sympathomimetic activity) is associated with fewer peripheral and chronotropic side effects than atenolol.
Answers are grounded in this paper and cite their sources.
Supports preferring pindolol over atenolol to minimize side effects in hypertension; extends RCT evidence for ISA beta-blockers.
A double-blind multicentre study of 349 hypertensive patients was performed to compare the side-effects of the two beta-blockers atenolol (selective beta 1-blocker) and pindolol (beta 1- and beta 2-blocker with Intrinsic sympathomimetic activity (ISA] in equipotential doses (100 mg atenolol vs. 15 mg pindolol). Male and female patients aged 20-65 years with essential hypertension WHO stages I and II were included. Patients were examined 1 and 6 months after the start of treatment, and side-effects were recorded. The antihypertensive effect was similar for the two drugs. After 1 month there was significantly less bradycardia (P less than 0.01), cold hands and feet (P less than 0.05) and tiredness (P less than 0.02) in the pindolol group, and less sleep disturbance (P less than 0.02) in the atenolol group. After 6 months there was no significant difference in sleep disturbance, but the differences in the other side-effects remained significant.
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Abrahamsen et al. (1990) conducted an RCT in Hypertension (n=349). Pindolol vs. Atenolol 100 mg was evaluated on Side-effects (bradycardia, cold hands and feet, tiredness, sleep disturbance). Pindolol resulted in less bradycardia, cold hands and feet, and tiredness compared to atenolol at 6 months in patients with hypertension.
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