A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

Q: What does this research mean for the field?

Atenolol, labetalol, metoprolol, and pindolol produce similar antihypertensive effects at varying doses, though labetalol presents slightly fewer overall side effects, pindolol causes more sleep disturbances, and atenolol and metoprolol result in a greater reduction in pulse rate. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

John J. McNeil; Louis Wj

doi:10.1111/j.1365-2125.1979.tb04774.x

April 1, 1979British Journal of Clinical PharmacologyOpen Access

A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

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Why the study?

Does the choice of beta-blocker (atenolol, labetalol, metoprolol, or pindolol) affect antihypertensive efficacy and side effect profile in patients with mild to moderate hypertension?

Structured PICO

Does the choice of beta-blocker (atenolol, labetalol, metoprolol, or pindolol) affect antihypertensive efficacy and side effect profile in patients with mild to moderate hypertension?

P

Population

Patients with mild to moderate hypertension

I

Intervention

Atenolol, labetalol, metoprolol, and pindolol (crossover design)

C

Comparator

Active comparators (crossover design)

O

Outcome

Antihypertensive effectssurrogate

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Implication

While atenolol, labetalol, metoprolol, and pindolol can achieve similar antihypertensive effects at varying doses, they differ in their effects on pulse rate and side effect profiles.

Abstract

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Cite This Study

McNeil et al. (1979) studied this question.

synapsesocial.com/papers/6a1bc21bea84844e355ee60f https://doi.org/10.1111/j.1365-2125.1979.tb04774.x

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A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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