Why the study?
Do once-daily atenolol, metoprolol, pindolol, and slow-release propranolol differ in their 24-hour blood pressure lowering effects in patients with newly diagnosed hypertension?
Population
34 patients with newly diagnosed hypertension
Comparison
Once-daily administration of atenolol… vs Head-to-head comparison among the four…
Design
RCT, randomised, double-blind
Follow-up
3 to 8 months (mean 5.0 +/- 1.4 months)
Authors
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Atenolol or slow-release propranolol support once-daily dosing for 24-hour control; extends RCT evidence differentiating beta-blocker durations in hypertension.
Do once-daily atenolol, metoprolol, pindolol, and slow-release propranolol differ in their 24-hour blood pressure lowering effects in patients with newly diagnosed hypertension?
Atenolol and slow-release propranolol are effective as once-daily antihypertensives over 24 hours, whereas metoprolol and pindolol may require more frequent dosing to maintain 24-hour blood pressure control.
Floras et al. (1982) studied this question.
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