Key result
Once-daily propranolol and atenolol produced a significant decline in blood pressure and pulse rate compared to placebo, whereas oxprenolol and metoprolol did not.
Why the study?
Do once-daily propranolol, atenolol, oxprenolol, or metoprolol reduce blood pressure compared to placebo in patients?
RCT (n=150)
Double-blind
Do once-daily propranolol, atenolol, oxprenolol, or metoprolol reduce blood pressure compared to placebo in patients?
Once-daily slow-release propranolol and atenolol effectively lower blood pressure, whereas once-daily oxprenolol and metoprolol do not show significant antihypertensive effects compared to placebo.
Supports once-daily propranolol or atenolol for hypertension; confirms differential beta-blocker efficacy in once-daily regimens.
The antihypertensive effect of four beta-blocking agents given once daily was compared with that of placebo in a prospective, crossover, double-blind study of 150 patients. The preparations tested were slow-release propranolol hydrochloride, 160 mg, atenolol, 100 mg, slow-release oxprenolol hydrochloride, 160 mg, and metoprolol, 200 mg. Propranolol and atenolol produced a significant decline in lying, standing, and postexercise blood pressure and pulse rate values. The effects of oxprenolol and metoprolol were not significantly different from that of placebo.
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Mordchai Ravid (1985) conducted an RCT in Hypertension (n=150). Propranolol, atenolol, oxprenolol, and metoprolol vs. Placebo was evaluated on Lying, standing, and postexercise blood pressure and pulse rate values. Once-daily propranolol and atenolol produced a significant decline in blood pressure and pulse rate compared to placebo, whereas oxprenolol and metoprolol did not.
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