Why the study?
Does beta 1-adrenoceptor blockade alter plasma levels of atrial natriuretic peptide during exercise in healthy volunteers?
Does beta 1-adrenoceptor blockade alter plasma levels of atrial natriuretic peptide during exercise in healthy volunteers?
Beta-1-adrenoceptor blockade increases ANP levels during exercise, suggesting tachycardia is not the primary stimulus for ANP release.
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Beta-1 blockade raises ANP during exercise in healthy volunteers; leaves open mechanisms of ANP release and relevance to patients.
Increased plasma levels of atrial natriuretic peptide (ANP) during exercise have been reported. To investigate the role of tachycardia as a stimulus for release of ANP during exercise the following study was undertaken. Graded exercise was performed in six healthy volunteers before and after beta 1-adrenoceptor blockade. Plasma levels of ANP were determined at different workloads in both cases. At rest and at all workloads during exercise plasma levels of ANP were higher after beta 1-adrenoceptor blockade than without. Therefore, it is unlikely that tachycardia is a major stimulus for secretion of ANP during exercise. It is suggested that increased right atrial pressure and/or pulmonary arterial blood pressure and increased plasma levels of catecholamines are important secretory stimuli for ANP during exercise.
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Thamsborg et al. (1987) studied this question.
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