October 3, 1994FEBS Letters

Removal of Mg2+ inhibition of cardiac ryanodine receptor by palmitoyl coenzyme A

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Population

Pig heart sarcoplasmic reticulum (cardiac ryanodine receptor channel)

Comparison

Palmitoyl coenzyme A vs Free coenzyme A or palmitic acid

Design

Preclinical

Authors

TCTimothy ConnellyRoslin Institute CAChristopher A. AhernUniversity of Iowa MSManana SukharevaLomonosov Moscow State University

Discussion

Member takes

Implication

May indicate a role for acyl-CoAs in cardiac Ca2+ release; hypothesis-generating and requires in vivo validation.

Structured PICO

Population

Pig heart sarcoplasmic reticulum (cardiac ryanodine receptor channel)

Intervention

Palmitoyl coenzyme A

Comparator

Free coenzyme A or palmitic acid

Outcome

Cardiac ryanodine receptor channel activity (measured by 45Ca2+ fluxes and planar bilayer recordings)surrogate

Palmitoyl CoA can reactivate cardiac ryanodine receptors inhibited by Mg2+, suggesting a mechanism by which cardiac muscle cells maintain Ca2+ store responsiveness.

Cite This Study

Connelly et al. (1994) studied this question.

synapsesocial.com/papers/6a70ac9dc92390ac2d07d15b https://doi.org/10.1016/0014-5793(94)00969-4

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Removal of Mg2+ inhibition of cardiac ryanodine receptor by palmitoyl coenzyme A

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Removal of Mg2+ inhibition of cardiac ryanodine receptor by palmitoyl coenzyme A

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider