Why the study?
Do fasting serum gastrin levels correlate with the degree of renal impairment in patients with chronic renal failure?
Population
89 patients with chronic renal failure
Design
Cohort
Authors
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Gastrin elevation tracks renal impairment severity in observational data; supports renal clearance hypothesis but remains hypothesis-generating without altering practice.
Do fasting serum gastrin levels correlate with the degree of renal impairment in patients with chronic renal failure?
The study suggests the kidney plays a role in the degradation of gastrin, as evidenced by elevated gastrin levels in chronic renal failure that improve with transplantation but not haemodialysis.
Korman et al. (1972) studied this question.
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