Key result
Chronic renal failure is linked to higher basal gastrin, predominantly G34LI, versus normal and ulcer subjects.
Population
68 patients with chronic renal failure, 15 patients with duodenal ulcer, and 15 normal subjects
Design
Cross-sectional
Authors
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May confound gastrin-based ulcer diagnostics in CRF; leaves open effects on acid secretion and clinical outcomes.
Observational (n=98)
Hypergastrinemia in chronic renal failure is characterized by elevated G34-like immunoreactivity and is likely due to reduced renal clearance and impaired negative acid feedback.
Muto et al. (2008) conducted an observational in Chronic Renal Failure (n=98). Chronic renal failure vs. Duodenal ulcer patients and normal subjects was evaluated on Basal plasma gastrin levels and gastric acid secretion. Chronic renal failure was associated with significantly higher basal gastrin concentrations compared to duodenal ulcer patients and normal subjects, with G34LI being a predominant circulating form.
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