Why the study?
Does carvedilol improve endothelial function and oxidative stress compared to metoprolol in patients with type 2 diabetes mellitus and hypertension?
Population
34 patients with type 2 diabetes mellitus (T2DM) and hypertension
Comparison
Carvedilol in addition to current… vs Metoprolol tartrate in addition to current…
Design
RCT, randomized
Follow-up
5 months
Authors
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Favors carvedilol over metoprolol for endothelial function in T2DM hypertension; extends beta-blocker comparative evidence independent of oxidative stress.
Does carvedilol improve endothelial function and oxidative stress compared to metoprolol in patients with type 2 diabetes mellitus and hypertension?
In patients with type 2 diabetes and hypertension, carvedilol significantly improves endothelial function compared to metoprolol, suggesting vascular protective effects beyond blood pressure lowering.
Bank et al. (2007) studied this question.
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