Why the study?
Does enalapril compared to losartan improve endothelial function and insulin sensitivity in essential hypertensive patients?
Population
24 essential hypertensive patients (18 in final analysis) and 12 sex- and age-matched normotensive controls
Comparison
Enalapril for 6 months vs Losartan for 6 months
Design
RCT, randomised into two groups
Follow-up
6 months
Authors
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May favor ACEIs over ARBs for insulin sensitivity in hypertension; extends class-specific metabolic effects beyond endothelial improvement.
Does enalapril compared to losartan improve endothelial function and insulin sensitivity in essential hypertensive patients?
Both ACE inhibitors and ARBs improve endothelial dysfunction in essential hypertension, but ACE inhibition may have a more prominent effect on improving insulin sensitivity and decreasing oxidative stress.
Yavuz et al. (2003) studied this question.
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