Tyrosine kinase and phosphatase regulation of slow delayed‐rectifier K⁺ current in guinea‐pig ventricular myocytes

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Population

Guinea-pig ventricular myocytes

Comparison

Tyrosine kinase inhibitors and phosphotyrosyl… vs Inactive analogues or baseline

Design

Preclinical

Authors

Discussion

TK inhibitors may alter repolarization in animal models; leaves open translation to human arrhythmia risk.

Population

Guinea-pig ventricular myocytes

Intervention

Tyrosine kinase inhibitors (tyrphostin A23, tyrphostin A25, genistein, AG1478, PP2) and phosphotyrosyl phosphatase inhibitor orthovanadate

Comparator

Inactive analogues (tyrphostin A1, tyrphostin A63, daidzein, genistin, PP3) or baseline

Outcome

Suppression of the slowly activating delayed-rectifier K(+) current (I(Ks))surrogate

Basal slowly activating delayed-rectifier K(+) current (I(Ks)) in guinea-pig ventricular myocytes is strongly dependent on tyrosine phosphorylation.

Missan et al. (2006) studied this question.

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