Tyrosine kinase and protein kinase C regulate L-type Ca2+current cooperatively in human atrial myocytes

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Population

Human atrial myocytes

Design

Preclinical

Authors

Discussion

No immediate clinical implications; leaves open whether tyrosine kinase inhibition of I(Ca) affects human cardiac electrophysiology or arrhythmias.

Population

Human atrial myocytes

Intervention

Tyrosine kinase inhibitors (genistein 50 microM, lavendustin A 50 microM, tyrphostin 23 50 microM) and protein kinase C modulators

Outcome

L-type Ca(2+) current (I(Ca))surrogate

In human atrial myocytes, tyrosine kinases inhibit L-type Ca2+ current via a mechanism involving protein kinase C.

Boixel et al. (2000) studied this question.

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No immediate clinical implications; leaves open whether tyrosine kinase inhibition of I(Ca) affects human cardiac electrophysiology or arrhythmias.