In patients taking low-dose aspirin for cardiovascular protection who develop peptic ulcer bleeding, early resumption of aspirin with a PPI is recommended to balance cardiovascular and bleeding risks.
Supports cautious aspirin resumption with PPI post-ulcer bleed; leaves open need for randomized confirmation.
Low-dose aspirin, defined as 75-325 mg daily, is widely used for the primary and secondary prevention of cardiovascular (CV) events. Currently, approximately 36% of the adult US population more than 50 million people are estimated to take aspirin regularly for CV protection The low-dose aspirin use may induce a wide range of adverse side effects in the upper gastrointestinal (GI) tract, which range from troublesome symptoms to life-threatening peptic ulcer bleeding, perforation [2] and even death
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Tsai et al. (2015) studied this question.
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