June 19, 2009Journal of Applied Physiology

Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects

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Why the study?

Are physiological changes during initial orthostatic hypotension related to orthostatic tolerance and syncope in healthy young subjects?

Structured PICO

Are physiological changes during initial orthostatic hypotension related to orthostatic tolerance and syncope in healthy young subjects?

Population

46 healthy young volunteers, mean age 25+/-5 years

Intervention

Standing upright for 3 min, followed by 60 degrees head-up tilt with lower-body negative pressure in 5-min increments of -10 mmHg until presyncope

Comparator

Standardized period of supine rest

Outcome

Relationship between cardiorespiratory and cerebrovascular changes during initial orthostatic hypotension (IOH) and those at presyncopesurrogate

Initial orthostatic hypotension and its associated transient physiological changes do not predict orthostatic tolerance or the development of syncope in healthy young individuals.

Discussion

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Implication

Initial orthostatic hypotension changes do not predict syncope in young adults; leaves open end-tidal CO2's role in presyncopal cerebral hypoperfusion.

Cite This Study

Thomas et al. (2009) studied this question.

synapsesocial.com/papers/6a70b91f660549caf2c5589e https://doi.org/10.1152/japplphysiol.91650.2008

View Full Paper

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Implication

Initial orthostatic hypotension changes do not predict syncope in young adults; leaves open end-tidal CO2's role in presyncopal cerebral hypoperfusion.

Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects

Structured PICO

Discussion

Implication

Cite This Study

Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider