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September 1, 2000Molecular Endocrinology

In adult males lacking IGFBP-2, spleen weight was reduced and liver weight was increased, accompanied by increased levels of IGFBP-1, IGFBP-3, and IGFBP-4 relative to wild-type mice.

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Why the study?

Does targeted disruption of the IGFBP-2 gene alter body growth or organ sizes in mice?

Population

Mice with a targeted disruption of the insulin-like growth factor binding protein-2 (IGFBP-2) gene

Comparison

Targeted disruption of the IGFBP-2 gene vs Wild-type mice

Design

Preclinical

Authors

TWTeresa L. WoodLRLeslie E. RoglerMCMaureen E. Czick

Discussion

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Overview

Organ size changes in IGFBP-2-null mice leave open its translational relevance to human growth and metabolism.

Structured PICO

Does targeted disruption of the IGFBP-2 gene alter body growth or organ sizes in mice?

P
Population
Mice with a targeted disruption of the insulin-like growth factor binding protein-2 (IGFBP-2) gene
I
Intervention
Targeted disruption of the IGFBP-2 gene (null IGFBP-2 allele)
C
Comparator
Wild-type mice
O
Outcome
Prenatal and postnatal body growth, organ weights (spleen and liver), and serum IGFBP levelssurrogate

Disruption of the IGFBP-2 gene in mice demonstrates its critical role in modulating spleen and liver size and leads to compensatory up-regulation of multiple other IGFBPs.

Cite This Study

Wood et al. (2000) studied this question.

synapsesocial.com/papers/6a70ba69e5469ee92be16b2chttps://doi.org/10.1210/mend.14.9.0517
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Alterations in Organ Sizes in Mice with a Targeted Disruption of the Insulin-Like Growth Factor Binding Protein-2 Gene2000 · 27 citations
  2. 2Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins2000 · 130 citations
  3. 3Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -52006 · 164 citations
  4. 4Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth<sup>1</sup>1997 · 123 citations
  5. 5Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo2008 · 119 citations