Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2

Male offspring of crossed hemizygous CMV-IGFBP-2 transgenic mice and hemizygous PEPCK-bGH transgenic mice, divided into four genetic groups: carrying both transgenes (GB), GH transgene (G), IGFBP-2 transgene (B), and nontransgenic controls (C).

Overexpression of IGFBP-2 (via CMV-IGFBP-2 transgene)

Nontransgenic controls (C) and GH-only transgenic mice (G)

Body and organ growth (body weight, carcass weight, nose-rump-length, organ weights) at 5 and 15 weeks of agesurrogate