February 3, 2004Endocrinology

Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities

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Population

IGFBP-6 transgenic mice expressing human IGFBP-6 cDNA under the control of the glial fibrillary acidic…

Comparison

Transgenic expression of human IGFBP-6 vs Wild-type mice

Design

Preclinical

Follow-up

Up to 6 months of age

Authors

GBG. BienvenuInserm DSDanielle SeurinInserm PGPascale Grellier

Discussion

Member takes

Implication

Warrants caution extrapolating IGFBP-6 CNS effects to humans; leaves open its role in developmental and reproductive disorders.

Structured PICO

Population

IGFBP-6 transgenic mice expressing human IGFBP-6 (hIGFBP-6) cDNA under the control of the glial fibrillary acidic protein (GFAP) promoter

Intervention

Transgenic expression of human IGFBP-6

Comparator

Wild-type mice

Outcome

Postnatal growth, brain development (cerebellum size/weight, astrocyte differentiation), and reproductive physiology (litter size, ovary weight, corpora lutea, LH levels)surrogate

Transgenic expression of IGFBP-6 in the CNS leads to impaired brain development, reduced postnatal growth, and significant reproductive abnormalities in mice.

Cite This Study

Bienvenu et al. (2004) studied this question.

synapsesocial.com/papers/6a8851709a71e8b12ff4dcd4 https://doi.org/10.1210/en.2003-1196

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Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider