January 1, 1997Journal of Endocrinology

Expression of insulin-like growth factor binding proteins (IGFBPs) in IGFBP-1 transgenic mice

View Full Paper

Ask AI

Bookmark

Population

Transgenic mice overexpressing a rat IGFBP-1 transgene driven by the phosphoglycerate kinase-1 promoter, and…

Comparison

Overexpression of rat IGFBP-1 transgene vs Wild-type (Wt) mice

Design

Preclinical

Authors

HHHeng HuangChongqing University KRK. RajkumarThe University of Texas Health Science Center at San Antonio LMLiam J. MurphyCreighton University

Discussion

Member takes

Implication

Tissue-specific IGFBP-1 mRNA changes in Tg mice warrant caution against clinical translation; leaves open differential transcriptional mechanisms for validation.

Structured PICO

Population

Transgenic (Tg) mice overexpressing a rat IGFBP-1 transgene driven by the phosphoglycerate kinase-1 promoter, and wild-type (Wt) mice

Intervention

Overexpression of rat IGFBP-1 transgene

Comparator

Wild-type (Wt) mice

Outcome

Hepatic and renal expressions of IGFBPs (mRNA levels)surrogate

Hepatic expression of the rat IGFBP-1 transgene in mice leads to a coordinated reduction in endogenous mouse IGFBP-1 mRNA levels.

Cite This Study

Huang et al. (1997) studied this question.

synapsesocial.com/papers/6a8bd6b7f8241cb45bfb6f20 https://doi.org/10.1677/joe.0.1520099

View Full Paper

Ask AI

Bookmark

Implication

Tissue-specific IGFBP-1 mRNA changes in Tg mice warrant caution against clinical translation; leaves open differential transcriptional mechanisms for validation.

Expression of insulin-like growth factor binding proteins (IGFBPs) in IGFBP-1 transgenic mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of insulin-like growth factor binding proteins (IGFBPs) in IGFBP-1 transgenic mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider