Key result
Overexpression of IGFBP-1 in transgenic mice significantly attenuated the hypoglycemic response to IGF-I (P < 0.05), leading to compensatory hyperinsulinemia and the gradual development of fasting hyperglycemia.
Why the study?
Does overexpression of human IGFBP-3 impair glucose homeostasis in male mice?
Does overexpression of human IGFBP-3 impair glucose homeostasis in male mice?
p-value: p=<0.05
Overexpression of human IGFBP-3 in transgenic mice results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance.
No takes yet. Share an insight, caveat, or question.
May link IGFBP-1 overexpression to impaired glycemia in mice; leaves open human relevance and IGFBP-3 effects.
Silha et al. (2002) studied Impaired glucose homeostasis. IGFBP-1 overexpression (Transgenic mice) vs. Wild-type mice was evaluated on Hypoglycemic response to IGF-I (p=<0.05). Overexpression of IGFBP-1 in transgenic mice significantly attenuated the hypoglycemic response to IGF-I (P < 0.05), leading to compensatory hyperinsulinemia and the gradual development of fasting hyperglycemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: