Population
Aging male IGFBP-3 transgenic mice (PGKBP3 and PGKmutBP3) and wild-type mice
Comparison
Overexpression of human IGFBP-3 or its mutant… vs Wild-type mice
Design
Preclinical
Follow-up
up to 12 months of age
Authors
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Animal data on IGFBP-3 variants should not alter practice; leaves open human relevance and mechanisms.
Overexpression of human IGFBP-3 or its mutant devoid of IGF binding ability leads to glucose intolerance in aging mice, but with divergent effects on insulin sensitivity and lipid homeostasis.
Nguyen et al. (2014) studied this question.
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