November 24, 2018Clinical Chemistry and Laboratory Medicine (CCLM)
A study of biological and lifestyle factors, including within-subject variation, affecting concentrations of growth differentiation factor 15 in serum
Why the study?
Growth differentiation factor 15 is an emerging cardiovascular biomarker with a recently available automated immunoassay, but its determinants, reference intervals, and within-subject biological variation needed evaluation.
Population
533 presumably healthy questionnaire-screened adults
Design
Observational cross-sectional and biological variation study
Authors
Discussion
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Member takes
Implication
Provides GDF-15 reference intervals from healthy adults; leaves open validation before clinical adoption.
Structured PICO
P
Population
533 presumably healthy questionnaire-screened adults, with a subgroup of 173 selected to establish reference intervals and 26 healthy volunteers for a biological variation substudy.
O
Outcome
Serum GDF-15 concentrations, reference intervals, and within-subject biological variationsurrogate
The study establishes a robust upper reference limit of 866 ng/L for serum GDF-15 in adults and demonstrates low intraindividual variation, supporting its use in longitudinal clinical monitoring.
Cite This Study
Krintus et al. (2018) studied this question.