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December 28, 2023Pakistan Journal of Medical & Health SciencesOpen Access

Histopathological grading of NAFLD demonstrated strong positive correlations with serum creatinine (r = 0.59, p<0.001) and urinary albumin (r = 0.71, p<0.001), and a negative correlation with eGFR (r = -0.64, p<0.001).

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Why the study?

The association between NAFLD and early renal dysfunction remains underexplored in South Asian women with PCOS.

Does NAFLD severity correlate with early renal dysfunction (serum creatinine, eGFR, urinary albumin) in women with PCOS?

Population

100 women with PCOS diagnosed by Rotterdam criteria

Comparison

Histopathological severity of NAFLD correlated with renal markers

Design

Cross-sectional analytical study

Authors

RARazwan AshrafHKHamid Nawaz KhokharAJAsma Jamil

Discussion

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Member takes

Overview

May signal early renal risk in PCOS with NAFLD; leaves open causal links and need for longitudinal confirmation.

Structured PICO

Does NAFLD severity correlate with early renal dysfunction (serum creatinine, eGFR, urinary albumin) in women with PCOS?

P
Population
100 women aged 18 to 45 years diagnosed with polycystic ovary syndrome (PCOS) based on the Rotterdam 2003 criteria, mean age 29.7. Excluded: known chronic liver diseases, pregnancy, previously diagnosed chronic kidney disease, use of hepatotoxic medications, and endocrine disorders (thyroid dysfunction, Cushing's syndrome).
O
Outcome
Correlation of NAFLD histopathological severity with serum creatinine, eGFR (CKD-EPI), and early-morning urinary albumin levelssurrogate

In women with PCOS, increasing severity of NAFLD is strongly correlated with early markers of renal impairment, suggesting that renal dysfunction begins prior to overt chronic kidney disease and highlighting the need for integrated metabolic screening.

Limitations

  • Cross-sectional design limits the ability to determine causal relationships
  • Liver biopsy was not performed in all participants, potentially affecting the interpretation of advanced fibrosis
  • Did not evaluate long-term renal outcomes
  • Did not evaluate the effect of therapeutic interventions such as weight reduction or insulin-sensitizing agents

Cite This Study

Ashraf et al. (2023) studied this question.

synapsesocial.com/papers/6a70baf7f44fa9f079de6eb4https://doi.org/10.53350/pjmhs02023172773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-alcoholic fatty liver disease in polycystic ovary syndrome women2021 · 42 citations
  2. 2Hepatic steatosis in women with polycystic ovary syndrome2023 · 17 citations
  3. 3Risk factors of Non Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome2025
  4. 4Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome2023 · 2 citations
  5. 5A Systematic Review of the Risk of Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome2022 · 10 citations