What question did this study set out to answer?

To determine whether compensatory left ventricular hypertrophy in essential hypertension normalizes myocardial oxygen consumption at the expense of reduced cardiac efficiency.

December 14, 1999CirculationOpen Access

Myocardial Oxygen Consumption Is Unchanged but Efficiency Is Reduced in Patients With Essential Hypertension and Left Ventricular Hypertrophy

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Population

27 men, comprising 9 hypertensive men with left ventricular hypertrophy, 8 hypertensive men without LVH, and…

Design

Cross-sectional

Authors

HLHanna LaineUniversity of Helsinki CKChietsugu KatohHokkaido University MLMatti LuotolahtiTurku University Hospital

Discussion

Member takes

Implication

Reduced myocardial efficiency in hypertensive LVH may signal HF predisposition; this cross-sectional association leaves causality open for prospective study.

Key Points

To determine whether compensatory left ventricular hypertrophy in essential hypertension normalizes myocardial oxygen consumption at the expense of reduced cardiac efficiency.
Assessed 9 hypertensive men with left ventricular hypertrophy (LVH+), 8 hypertensive men without LVH (LVH-), and 10 normotensive men (CONT).
Measured myocardial blood flow, oxygen consumption, and glucose uptake using PET during euglycemic hyperinsulinemia, and calculated myocardial workload and efficiency using echocardiography.
Myocardial blood flow (1.06±0.22 vs 0.81±0.09 and 0.84±0.16 mL·g⁻¹·min⁻¹) and oxygen consumption (0.14±0.03 vs 0.11±0.01 and 0.09±0.02 mL·g⁻¹·min⁻¹) were elevated in LVH- compared with LVH+ and CONT (P<0.05).
Myocardial efficiency was significantly decreased in the LVH+ group (13.5±1.9%) compared with normotensive controls (18.1±4.1%, P<0.05), whereas LVH- measured 15.1±2.3%.

Structured PICO

Population

27 men, comprising 9 hypertensive men with left ventricular hypertrophy (LVH+) (age 42+/-2 years), 8 hypertensive men without LVH (LVH-) (age 39+/-5 years), and 10 normotensive men (CONT).

Comparator

Normotensive men (CONT) and hypertensive men without LVH (LVH-)

Outcome

Myocardial oxygen consumption, myocardial blood flow, and myocardial efficiency measured during euglycemic hyperinsulinemia using PET techniques and echocardiographysurrogate

In hypertensive patients, compensatory left ventricular hypertrophy normalizes myocardial oxygen consumption per unit weight but significantly reduces myocardial efficiency, which may predispose these patients to heart failure.

Cite This Study

Laine et al. (1999) studied this question.

synapsesocial.com/papers/6a70bb46b5c1fe5ca9dfc016 https://doi.org/10.1161/01.cir.100.24.2425

Topics

Hypertension management Echocardiography

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Implication

Reduced myocardial efficiency in hypertensive LVH may signal HF predisposition; this cross-sectional association leaves causality open for prospective study.

Myocardial Oxygen Consumption Is Unchanged but Efficiency Is Reduced in Patients With Essential Hypertension and Left Ventricular Hypertrophy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Myocardial Oxygen Consumption Is Unchanged but Efficiency Is Reduced in Patients With Essential Hypertension and Left Ventricular Hypertrophy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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