What question did this study set out to answer?

May 21, 2017European Heart JournalOpen Access

SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve

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Population

1,946 patients undergoing transcatheter aortic valve implantation enrolled in 80 centres from 10 European…

Design

Cohort

Follow-up

1 year

Authors

OWOlaf WendlerCardiac Surgery GSGerhard SchymikInterventional / Structural Cardiology HTHendrik TreedeCardiac Surgery

Discussion

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Implication

Low event rates may support TAVI consideration in elderly intermediate-risk patients; leaves open randomized comparisons to surgery.

Key Points

The study aims to evaluate the 1-year outcomes following transcatheter aortic valve implantation using the SAPIEN 3 valve in intermediate risk elderly patients.
Data were prospectively collected from 1946 patients enrolled in 80 centers across 10 European countries.
Outcomes were adjudicated by an independent committee following VARC-2 definitions.
The study assessed various endpoints including mortality rates and complications.
All-cause mortality was 12.6% at 1 year, with cardiovascular mortality at 8.0%.
Stroke rates were 3.1%, with disabling stroke at 1.4% and new pacemaker insertion at 13.2%.
Severe paravalvular leakage occurred in 2.6% of patients, suggesting a low incidence of higher degree leaks.

Structured PICO

Population

1,946 patients undergoing transcatheter aortic valve implantation (mean age 81.6 ± 6.7 years, 52% male) enrolled in 80 centres from 10 European countries.

Intervention

Transcatheter aortic valve implantation using the balloon-expandable SAPIEN 3 transcatheter heart valve

Outcome

All-cause mortality at 1 yearhard clinical

The SAPIEN 3 transcatheter heart valve demonstrates low 1-year mortality and complication rates, with rare moderate or severe paravalvular leakage in a real-world European registry.

Cite This Study

Wendler et al. (2017) studied this question.

synapsesocial.com/papers/6a70bb5931a3df824328fbe5 https://doi.org/10.1093/eurheartj/ehx294

Topics

Transcatheter aortic valve replacement TAVR in low-risk patients

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SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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