Key result
Sapien 3 valve-in-valve implantation resolves paravalvular leak with 0% 30-day mortality.
Why the study?
Paravalvular leakage is a known complication of TAVI associated with poor outcomes, and valve-in-valve procedures with the latest generation balloon-expandable devices for failing THVs require evaluation.
Case Report (n=3)
No
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for Sapien 3 valve-in-valve in residual leak; should not change practice pending larger studies.
Schaefer et al. (2016) conducted a case report in Failing transcatheter heart valves with paravalvular leakage (n=3). Edwards Sapien 3 transcatheter heart valve (valve-in-valve procedure) was evaluated on Successful implantation with significant reduction of paravalvular leakage to none/trace. Valve-in-valve deployment of the Edwards Sapien 3 transcatheter heart valve successfully reduced residual paravalvular leakage to none or trace in all three patients, with 0% 30-day mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: