Population
Platelets (in vitro model of platelet adhesion on von Willebrand factor under flow)
Design
Preclinical
Authors
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Distinguishes reversible from irreversible platelet adhesion via calcium signals; leaves open translation to human thrombosis models.
The study reveals a dual-step calcium signaling mechanism involving GPIb and integrin alpha(IIb)beta(3) that cooperatively regulates platelet adhesion dynamics under flow.
Nesbitt et al. (2002) studied this question.
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