September 15, 2017ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure

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Why the study?

Does PR interval prolongation predict worse survival in patients with heart failure?

Population

3,664 consecutive patients referred with suspected heart failure in sinus rhythm without ventricular pacing…

Comparison

PR interval prolongation vs Normal PR interval (shorter PRc quartiles)

Design

Cohort

Follow-up

Median 3.9 years, 3.7 years, 7.9 years

Authors

TNTheodora NikolaidouUniversity of Hull PPPierpaolo PellicoriHeart Failure & Transplant JZJufen ZhangAmicus Therapeutics (United Kingdom)

Discussion

Member takes

Implication

PR prolongation signals higher mortality in suspected HF; leaves open independent prognostic value and any therapeutic implications.

Structured PICO

Does PR interval prolongation predict worse survival in patients with heart failure?

Population

3,664 consecutive patients referred with suspected heart failure in sinus rhythm without ventricular pacing devices, including 1,420 with heart failure and reduced ejection fraction (HeFREF), 1,094 with heart failure and normal ejection fraction (HeFNEF), and 1,150 without heart failure.

Intervention

PR interval prolongation (first-degree heart block, heart rate corrected PR interval [PRc] > 200 ms or longest PRc quartile)

Comparator

Normal PR interval (shorter PRc quartiles)

Outcome

All-cause mortalityhard clinical

PR interval prolongation is common in patients with heart failure and is associated with worse survival in unadjusted analyses, though it is not an independent predictor of mortality.

Limitations

Only patients with a documented ECG at 1 year were included in the 1-year analysis, which may have resulted in selection bias.

Cite This Study

Nikolaidou et al. (2017) studied this question.

synapsesocial.com/papers/6a70c52be71d69abee08d4fc https://doi.org/10.1007/s00392-017-1162-6

Topics

HFrEF treatment Cardiac device therapy Heart failure HFpEF management

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Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider