The Thermogenic Effect of Thyroid Hormone and Its Clinical Implications

Reviews5 August 2003The Thermogenic Effect of Thyroid Hormone and Its Clinical ImplicationsJ. Enrique Silva, MDJ. Enrique Silva, MDFrom Jewish General Hospital, Montreal, Quebec, Canada.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesThere is a popular belief, even among physicians, that weight changes are frequent manifestations of thyroid dysfunction.Thyrotoxicosis is usually associated with weight loss and heat intolerance. Cold intolerance, but not weight gain, is a prominent feature of hypothyroidism.Pathophysiologic PrinciplesThyroid hormones increase heat production only in homeothermic species.Thermogenesis is energy dissipation as heat.The thermogenic effect of thyroid hormones is closely linked to increased appetite and lipogenesis to ensure fuel availability and avoid wasting.Major thermogenic mechanisms include increased turnover of adenosine triphosphate (ATP) and programmed reduction in the efficiency of ATP synthesis.Reduced efficiency in ATP synthesis is relatively more important than ...References1. Else PL, Hulbert AJ. Comparison of the mammal machine and the reptile machine: energy production. Am J Physiol. 1981;240:R3-9. [PMID: 6257122] MedlineGoogle Scholar2. Woledge RC. Energy transformations in living muscle.. In: Wieser W, Gnaiger E, eds. Energy Transformations in Cells and Organisms. New York: Georg Thieme Verlag; 1989:36-45. Google Scholar3. 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Google Scholar Author, Article, and Disclosure InformationAffiliations: From Jewish General Hospital, Montreal, Quebec, Canada.Grant Support: By grants from the Medical Research Council of Canada (MT-11550, MT-15101) and Canadian Institutes of Health Research (MOP-44071).Disclosures: None disclosed.Corresponding Author: J. Enrique Silva, MD, Division of Endocrinology, Jewish General Hospital, Room E-104, 3755 Chemin de la Cte-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada; e-mail, enrique.[email protected]mcgill.ca. 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