Population
Single muscle fibers
Comparison
Exposure to hypertonic solutions by addition of… vs Normal Ringer solution and hypotonic media
Design
Preclinical
Authors
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Hyperosmotic solute effects on muscle function differ in animal models; leaves open relevance to human cardiac excitability or practice.
Different hyperosmotic solutes exert distinct transient or sustained effects on muscle fiber volume and twitch tension, with some causing irreversible functional loss upon return to isotonic conditions.
Carlo Caputo (1968) studied this question.
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