November 29, 2007Journal of Applied Physiology

Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships

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Population

Isolated rat hearts

Design

Preclinical

Authors

KCKenneth B. CampbellUniversity of Kentucky ASAmy SimpsonWest Virginia University SCStuart G. CampbellYale University

Discussion

Member takes

Implication

Reproduces rat LV pressure responses; extends contractile modeling but leaves open human translation.

Structured PICO

Population

Isolated rat hearts

Intervention

Mathematical model of dynamic left ventricular elastance integrating myocardial contractile processes

Outcome

Ability to reproduce cycle-time-dependent LV pressure response (DeltaP(t)) to incremental step-like volume changes (DeltaV)

A novel mathematical model successfully integrates myocardial contractile processes into LV function, accurately reproducing LV pressure responses in isolated rat hearts.

Cite This Study

Campbell et al. (2007) studied this question.

synapsesocial.com/papers/6a70c7c92163a0a01bc4fbdf https://doi.org/10.1152/japplphysiol.00912.2007

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Ask AI

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Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider