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July 1, 1983AJP Heart and Circulatory Physiology

Left ventricular systolic dynamics in terms of its chamber mechanical properties

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Population

Isolated canine hearts

Design

Preclinical

Authors

SSSanjeev G. ShroffGeneral CardiologyJJJoseph S. JanickiHeart Failure & TransplantKWK. T. WeberIdaho State University

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Implication

Supports single-beat LV elastance estimation in animal models; leaves open human validation before clinical use.

Key Points

  • To characterize the mechanical properties of the left ventricle as a pump by developing and validating a mathematical model of its systolic dynamics.
  • Formulated a model based on elastance, resistance, and inertance, determining parameter functions using the flow-pulse response technique in isolated, isovolumetrically beating canine hearts (n=3 experiments).
  • Tested the simplified elastance-resistance model across 225 combinations of end-diastolic volume, ejection pressure, heart rate, and contractile state in 10 canine experiments during ejecting cardiac cycles.
  • Inertance was found to be negligible, allowing systolic dynamics to be modeled with elastance as a third-order polynomial in time and resistance as a linear function of instantaneous left ventricular pressure.
  • Ventricular elastance was insensitive to end-diastolic volume and ejection pressure but depended on contractile state and heart rate, whereas the linear resistance-pressure relationship remained insensitive to all four variables.
  • The model prospectively and accurately predicted left ventricular isovolumetric pressure waveforms using flow and pressure data measured from ejecting beats.

Structured PICO

P
Population
Isolated canine hearts (10 experiments, 225 combinations of end-diastolic volume, ejection pressure, heart rate, and contractile state)
I
Intervention
Mathematical modeling of left ventricular systolic dynamics using flow-pulse response technique
O
Outcome
Intrinsic chamber mechanical properties (systolic elastance and resistance)surrogate

A simplified mathematical model of left ventricular systolic dynamics can accurately calculate intrinsic chamber mechanical properties (elastance and resistance) from a single ejecting beat.

Cite This Study

Shroff et al. (1983) studied this question.

synapsesocial.com/papers/6a70c7cb2163a0a01bc4fbebhttps://doi.org/10.1152/ajpheart.1983.245.1.h110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships2007 · 20 citations
  2. 2Time-Varying Mechanical Properties of the Left Ventricle-A Computer Simulation1985 · 32 citations
  3. 3Systolic mechanical properties of the left ventricle. Effects of volume and contractile state.1983 · 94 citations
  4. 4Functional requirements of a mathematical model of the heart2009 · 3 citations
  5. 5Modeling left ventricular dynamics using a switched system approach based on a modified atrioventricular piston unit2018 · 5 citations