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March 1, 1983Circulation ResearchOpen Access

Systolic mechanical properties of the left ventricle. Effects of volume and contractile state.

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Population

Isovolumically beating, isolated canine heart preparation

Comparison

Step-like perturbations in ventricular volume… vs Control state

Design

Preclinical

Authors

WHWilliam C. HunterUniversity of WashingtonJJJoseph S. JanickiHeart Failure & TransplantKWK. T. WeberIdaho State University

Discussion

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Implication

Supports end-systolic elastance sensitivity to inotropy in isolated hearts; leaves open clinical translation of ESPVR for contractility assessment.

Key Points

  • The aim is to characterize how volume changes affect the mechanical properties of the contracting left ventricle.
  • Studied isolated canine hearts under isovolumic conditions.
  • Monitored left ventricular systolic pressure changes with volume perturbations (+/- 3 ml).
  • Measured elasticity, resistance, and deactivation effects using variable contractile states from dobutamine.
  • Elastic stiffness increased by 40% above baseline (5.1 mm Hg/ml) in response to contractile state changes, raising peak isovolumetric pressure by 54%.
  • Resistance averaged 0.11 mm Hg/ml per sec at 100 mm Hg, showing a linear increase with ventricular pressure.
  • Deactivation was more pronounced with later imposed volume steps, independent of filling volume or contractile state changes.

Structured PICO

P
Population
Isovolumically beating, isolated canine heart preparation
I
Intervention
Step-like perturbations (+/- 3 ml) in ventricular volume and dobutamine (2-13 micrograms/min)
C
Comparator
Control state
O
Outcome
Changes in left ventricular systolic pressure and mechanical properties (elasticity, resistance, and deactivation effect)surrogate

Elasticity, or the end-systolic pressure-volume relationship, is the mechanical property most sensitive to changes in contractile state, supporting its use to quantify contractility.

Cite This Study

Hunter et al. (1983) studied this question.

synapsesocial.com/papers/6a70c7cb2163a0a01bc4fbechttps://doi.org/10.1161/01.res.52.3.319
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The deformational characteristics of the left ventricle in the conscious dog.1981 · 72 citations
  2. 2Load Independence of the Instantaneous Pressure-Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio1973 · 1,526 citations
  3. 3Left ventricular stiffness during diastole and systole: the influence of changes in volume and inotropic state1972 · 67 citations
  4. 4Left ventricular wall acceleration and the law of Laplace1970 · 37 citations