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Does right common carotid artery intima-media thickness predict cardiovascular events differently than left common carotid artery intima-media thickness in patients with stable coronary artery disease?
Does right common carotid artery intima-media thickness predict cardiovascular events differently than left common carotid artery intima-media thickness in patients with stable coronary artery disease?
Right CCA IMT, but not left CCA IMT, is an independent predictor of cardiovascular events in patients with stable CAD, suggesting side-specific prognostic value.
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Right CCA IMT was associated with events in stable CAD; hypothesis-generating and should not yet change practice.
Population-based studies have demonstrated differences in intima-media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between the left and right CCAs and the composite end point of cardiac death or nonfatal acute coronary syndrome among 149 patients with angiographically confirmed stable CAD were studied. A total of 22 patients had cardiovascular events during the 32.1 ± 10.9 months follow-up. Multivariate analysis revealed that prior ischemic stroke (hazard ratio [HR]: 15.36, 95% confidence interval [CI]: 4.49-52.59, P < .001), extent of CAD (HR: 1.56, 95%CI: 1.01-2.42, P = .046), and right CCA IMT (HR: 17.07, 95%CI: 2.16-134.69, P = .007) but not the left CCA IMT, independently predicted cardiovascular events. The right CCA IMT independently predicted event-free survival among patients with established CAD, suggesting that the left and right CCA may exhibit different prognostic values in our population.
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Lee et al. (2010) studied this question.
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