January 7, 1997Circulation
Dobutamine Enhances Cardiodepressant Effects of Receptor-Mediated Coronary Endothelial Stimulation
Why the study?
Does dobutamine enhance the cardiodepressant effects of intracoronary substance P in patients with cardiac transplantation or dilated cardiomyopathy?
Population
16 patients, including 13 after cardiac transplantation and 3 with dilated nonischemic cardiomyopathy
Comparison
Intracoronary infusion of substance P for 5… vs Intracoronary infusion of substance P for 5…
Design
Other
Follow-up
5 minutes
Authors
Discussion
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Member takes
Implication
May potentiate endothelial cardiodepression via beta-adrenergic interaction in transplant and cardiomyopathy; leaves open clinical relevance pending validation.
Structured PICO
Does dobutamine enhance the cardiodepressant effects of intracoronary substance P in patients with cardiac transplantation or dilated cardiomyopathy?
P
Population
16 patients, including 13 after cardiac transplantation and 3 with dilated nonischemic cardiomyopathy
I
Intervention
Intracoronary infusion of substance P (20 pmol/min) for 5 minutes during concurrent intravenous administration of dobutamine
C
Comparator
Intracoronary infusion of substance P (20 pmol/min) for 5 minutes under control conditions (without dobutamine)
O
Outcome
Change in left ventricular end-systolic pressure and left ventricular peak systolic pressuresurrogate
Dobutamine enhances the cardiodepressant effect of receptor-mediated coronary endothelial stimulation, likely through a potentiating interaction with beta-adrenergic stimulation.
Cite This Study
Bartúnek et al. (1997) studied this question.