March 1, 1988British Journal of Clinical PharmacologyOpen Access

Pimobendane (UD‐CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross‐over and double‐blind study with two different doses.

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Why the study?

Does oral pimobendane improve haemodynamics in patients with chronic congestive heart failure?

Population

8 patients suffering from chronic congestive heart failure

Comparison

Oral pimobendane 10 mg single dose vs Oral pimobendane 5 mg single dose

Design

RCT, randomized cross-over, double-blind

Follow-up

12 hours after each dose

Authors

MWM WalterUniversity of Liège ILIsabelle LiebensAmerican College of Cardiology HGH GoethalsKU Leuven

Discussion

Member takes

Implication

Supports pimobendan for acute haemodynamic improvement in severe CHF; extends dose-response data on preload reduction.

Structured PICO

Does oral pimobendane improve haemodynamics in patients with chronic congestive heart failure?

Population

8 patients suffering from chronic congestive heart failure

Intervention

Oral pimobendane 10 mg single dose

Comparator

Oral pimobendane 5 mg single dose (randomized cross-over design)

Outcome

Haemodynamics (left and right ventricular functions, pulmonary wedge pressure, right atrial pressure, cardiac index) and plasma levels of pimobendane and its main metabolite UD-CG 212 measured up to 12 hours after each dosesurrogate

Oral pimobendane acutely improves haemodynamics in patients with severe chronic congestive heart failure, with higher doses providing greater reductions in right atrial and pulmonary wedge pressures.

Cite This Study

Walter et al. (1988) studied this question.

synapsesocial.com/papers/6a70c8a5fe4101aa97e04f22 https://doi.org/10.1111/j.1365-2125.1988.tb03310.x

Topics

Heart failure HFrEF treatment

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Ask AI

Bookmark

Pimobendane (UD‐CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross‐over and double‐blind study with two different doses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Pimobendane (UD‐CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross‐over and double‐blind study with two different doses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider