Population
Cohort of patients selected for a likely familial component to their hypertension, and in vitro models for…
Design
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No renin prosegment mutations or hypertension link identified; leaves open whether other genetic variants influence RAS activation.
Structure-function studies and genetic screening suggest that mutation of the prorenin prosegment is an unlikely factor in the activation of the renin-angiotensin system in humans.
Mercure et al. (1995) studied this question.
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